Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity. Guzman-Karlsson, M.C., Meadows, J.P., Gavin, C.F., Hablitz, J.J. Finally, our data provide evidence for a molecular framework of memory acquisition and maintenance, wherein DNA methylation could alter the expression and splicing of genes involved in functional plasticity and synaptic wiring. Although long-lasting changes were almost exclusive to neurons, learning-related histone modification and DNA methylation changes also occurred in non-neuronal cell types, suggesting a functional role for non-neuronal cells in epigenetic learning. We found that histone modifications predominantly changed during memory acquisition and correlated surprisingly little with changes in gene expression. In an effort to unravel the epigenetic network underlying both short- and long-term memory, we examined chromatin modification changes in two distinct mouse brain regions, two cell types and three time points before and after contextual learning. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. The ability to form memories is a prerequisite for an organism's behavioral adaptation to environmental changes.